mLab Goals

Localised translation is an essential mechanism of symmetry breaking enabling processes as body axis formation in development, cell migration and long-term memory formation. mRNA–MT cytoskeleton interactions are the basis required for mRNA transport, anchoring and possibly translation control.

Our lab investigates for the direct interplay between MTs and their associated proteins with different types of RNAs and their binding proteins in defined, dynamic in vitro systems. Focus is set on a quantitative understanding of the function of MAPs and RBPs in mRNA transport, mRNP formation and translational control by novel assays aiming to reconstitute minimal mRNPs exhibiting motile behaviour and translational control.