PROJECT DESCRIPTION

In an attempt to understand the composition of neuronal mRNA transport machineries, our lab has recently established a high-throughput matrix-interaction screening approach, revealing several novel interactions between microtubule-associated proteins (MAPs) and RNA-binding proteins (RBPs).

I am interested in characterizing these novel interactions, thereby focusing on the question of how neuronal mRNA transport is regulated. To address this question, I use microscopy-coupled biochemical in vitro reconstitution techniques.

 

CV

Since May 2018: Ph.D. student in the laboratory of Dr. Sebastian Maurer at the Center for Genomic Regulation (CRG), Barcelona, Spain

2017 – 2018:  Master thesis in the laboratory of Prof. Andres Jäschke, Heidelberg University, Heidelberg, Germany

2016:  Research internship in the laboratory of Prof. Alan Engelman, Dana-Farber Cancer Institute, Boston, USA

2014 – 2018:  M. Sc. in Molecular Biotechnology, Heidelberg University, Heidelberg, Germany

2011 – 2014: B. Sc. in Molecular Biotechnology, Heidelberg University, Heidelberg, Germany

 

PUBLICATIONS

Grawenhoff J & Engelman AN (2017). Retroviral integrase protein and intasome nucleoprotein complex structures. World Journal of Biological Chemistry 8: 32-44

Höfer K, Li S, Abele F, Frindert J, Schlotthauer J, Grawenhoff J, Du J, Patel DJ, Jäschke A (2016). Structure and function of the bacterial decapping enzyme NudC. Nature Chemical Biology 12: 730-734