After successfully finishing the development and validation of the rec-YnH screening pipeline, Mireia moved on to a new job in the lab of Andras Gyorgy. We wish her all the best for the future and are very thankful for all the hard and great work done in our lab.
PROJECT DESCRIPTION
In an effort to understand the key players and the mechanisms involved in mRNA transport in mammalian neurons, I am developing novel high-throughput screening technique in collaboration with the Serrano lab at CRG to identify important direct protein-protein and RNA-protein interactions.
CV
Since 2013: Research technician at the laboratory of Dr Sebastian Maurer at the Centre for Genomic Regulation, in Barcelona, Spain
2006 – 2013: Senior postdoc in Dr Mark Isalan’s laboratory at the Centre for Genomic Regulation
2003 – 2005: Research Associate at the University of Wisconsin-Madison working with Dr Avtar Roopra’s and Prof Peggy J. Farnham
2001 – 2003: Research fellow at Harvard medical School in Prof Stuart H. Orkin’s laboratory
1997 – 2001 Wellcome Prize PhD student at University College London, UK in the laboratory of Prof. Noel J. Buckley
1996 -1997: Research assistant in the laboratory of Prof. Noel J. Buckley
1991 -1996 UNIVERSITY OF BARCELONA, SPAIN First Class Hons B.Sc. in Chemistry (Major in Biochemistry)
PUBLICATIONS
Garriga-Canut M, Agustín-Pavón C, Herrmann F, Sánchez A, Dierssen M, Fillat C, Isalan M. “Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.” Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3136-45
Herrmann F, Garriga-Canut M, Baumstark R, Fajardo-Sanchez E, Cotterell J, Minoche A, Himmelbauer H, Isalan M. “p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing.”PLoS One . 2011;6(6):e20913. Epub 2011 Jun 9.
Isalan M, Lemerle C, Michalodimitrakis K, Horn C, Beltrao P, Raineri E, Garriga-Canut M, Serrano L. “Evolvability and hierarchy in rewired bacterial gene networks.” Nature. 2008 Apr 17;452(7189):840-5.
Garriga-Canut M, Schoenike B, Qazi R, Bergendahl K, Daley TJ, Pfender R, Morrison JF, Ockuly J, Stafstrom C, Sutula T, Roopra A. “Epilepsy progression is reduced by 2-deoxy-D-glucose and is associated with NRSF-CtBP dependent metabolic regulation of chromatin structure”. Nat. Neurosc. 2006: Nov;9(11):1382-7
Li Z, Godinho F, Klusmann J-H, Garriga-Canut M, Yu C and Orkin SH. “Developmental Stage-Selective Effect of Somatically Mutated Leukemogenic Transcription Factor – GATA-1”. Nat Gen . 2005 Jun;37(6):613-9
Garriga-Canut M, Orkin SH. “TACC3 controls FOG-1 subcellular localization and blocks assoctiation between GATA-1 and FOG-1 during hematopoiesis”. J. Biol. Chem . 2004: 279 (22): 23597-23605
Garriga-Canut M, Roopra A, Buckley NJ. “The basic helix-loop-helix protein, sharp-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism”. J. Biol. Chem . 2001: 276 (18): 14821-14828
Wood IC*, Garriga Canut M*, Palmer CL, Pepitoni S, Buckley NJ. “Neuronal expression of the rat M1 muscarinic acetylcholine receptor gene is regulated by elements in the first exon”. Biochem J 1999 Jun 1;340 ( Pt 2):475-83. *These two authors contributed equally to the work