PROJECT DESCRIPTION
In an effort to understand the key players and the mechanisms involved in mRNA transport in mammalian neurons, I am developing novel high-throughput screening technique in collaboration with the Serrano lab at CRG to identify important direct protein-protein and RNA-protein interactions.
CV
Since 2013: Research technician at the laboratory of Dr Sebastian Maurer at the Centre for Genomic Regulation, in Barcelona, Spain
2006 – 2013: Senior postdoc in Dr Mark Isalan’s laboratory at the Centre for Genomic Regulation
2003 – 2005: Research Associate at the University of Wisconsin-Madison working with Dr Avtar Roopra’s and Prof Peggy J. Farnham
2001 – 2003: Research fellow at Harvard medical School in Prof Stuart H. Orkin’s laboratory
1997 – 2001 Wellcome Prize PhD student at University College London, UK in the laboratory of Prof. Noel J. Buckley
1996 -1997: Research assistant in the laboratory of Prof. Noel J. Buckley
1991 -1996 UNIVERSITY OF BARCELONA, SPAIN First Class Hons B.Sc. in Chemistry (Major in Biochemistry)
PUBLICATIONS
Garriga-Canut M, Agustín-Pavón C, Herrmann F, Sánchez A, Dierssen M, Fillat C, Isalan M. “Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.” Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3136-45
Herrmann F, Garriga-Canut M, Baumstark R, Fajardo-Sanchez E, Cotterell J, Minoche A, Himmelbauer H, Isalan M. “p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing.”PLoS One . 2011;6(6):e20913. Epub 2011 Jun 9.
Isalan M, Lemerle C, Michalodimitrakis K, Horn C, Beltrao P, Raineri E, Garriga-Canut M, Serrano L. “Evolvability and hierarchy in rewired bacterial gene networks.” Nature. 2008 Apr 17;452(7189):840-5.
Garriga-Canut M, Schoenike B, Qazi R, Bergendahl K, Daley TJ, Pfender R, Morrison JF, Ockuly J, Stafstrom C, Sutula T, Roopra A. “Epilepsy progression is reduced by 2-deoxy-D-glucose and is associated with NRSF-CtBP dependent metabolic regulation of chromatin structure”. Nat. Neurosc. 2006: Nov;9(11):1382-7
Li Z, Godinho F, Klusmann J-H, Garriga-Canut M, Yu C and Orkin SH. “Developmental Stage-Selective Effect of Somatically Mutated Leukemogenic Transcription Factor – GATA-1”. Nat Gen . 2005 Jun;37(6):613-9
Garriga-Canut M, Orkin SH. “TACC3 controls FOG-1 subcellular localization and blocks assoctiation between GATA-1 and FOG-1 during hematopoiesis”. J. Biol. Chem . 2004: 279 (22): 23597-23605
Garriga-Canut M, Roopra A, Buckley NJ. “The basic helix-loop-helix protein, sharp-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism”. J. Biol. Chem . 2001: 276 (18): 14821-14828
Wood IC*, Garriga Canut M*, Palmer CL, Pepitoni S, Buckley NJ. “Neuronal expression of the rat M1 muscarinic acetylcholine receptor gene is regulated by elements in the first exon”. Biochem J 1999 Jun 1;340 ( Pt 2):475-83. *These two authors contributed equally to the work
