Silvia Speroni







I am using the rec-YnH screen developed in the lab to identify direct protein-protein and RNA-protein interactions of importance for cytoplasmic mRNA distribution. The goal is to provide new insights into the molecular mechanisms underlying mammalian mRNA localization and to further develop rec-Y3H screening for large scale applications.



Since 2019:        Research Technician in the laboratory of Dr. Sebastian Maurer at the Centre  for Genomic Regulation (CRG), Barcelona, Spain

2017-2018:         Lab Engineer & Technology Development Specialist at Centro Nacional de Análisis Genómico (CNAG-CRG) – PCB Barcelona

2013-2016:         Research Technician at the BioMolecular Screening & Protein Technologies Facility at the Centre de Regulaciò Genomica (CRG) – PRBB Barcelona

2008-2013:         Research Technician at the Protein Expression Facility at the Centre de Regulaciò Genomica (CRG) – PRBB Barcelona

2005-2008:         PhD in Biocrystallography, University of Pavia, Italy

2000-2005:        Bachelor and Master in Industrial and Environmental Biotechnology, University of Milan, Italy.



Mireia Garriga-Canut, Jae-Seong Yang, Friedrich Preußer, Silvia Speroni, Maria Gili, Sebastian Paul Moritz Maurer rec-Y3H screening allows the detection of simultaneous RNA-protein interface mutations Methods 2019. Under revision

Dos Santos HG, Abia D, Janowski R, Mortuza G, Bertero MG, Boutin M, Guarín N, Méndez-Giraldez R, Nuñez A, Pedrero JG, Redondo P, Sanz M, Speroni S, Teichert F, Bruix M, Carazo JM, Gonzalez C, Reina J, Valpuesta JM, Vernos I, Zabala JC, Montoya G, Coll M, Bastolla U, Serrano L. Structure and non-structure of centrosomal proteins. PLoS One. 2013 May 9;8(5)

Hermoso A, Bertero M, Speroni S, Alloza M, Roma G. Lab Service Wiki: a wiki-based data management solution for laboratories production services SemWiki2010 – Conference Proceedings. 2010 May.

 Bollati M, Alvarez K, Assenberg R, Baronti C, Canard B, Cook S, Coutard B, Decroly E, de Lamballerie X, Gould EA, Grard G, Grimes JM, Hilgenfeld R, Jansson AM, Malet H, Mancini EJ, Mastrangelo E, Mattevi A, Milani M, Moureau G, Neyts J, Owens RJ, Ren J, Selisko B, Speroni S, Steuber H, Stuart DI, Unge T, Bolognesi M.

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design. Antiviral Res  2009 Speroni S, Rohayem J, Nenci S, Bonivento D, Robel I, Barthel J, Luzhkov VB, Coutard B, Canard B, Mattevi A Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 A resolution. J Mol Biol. 2009, 387(5):1137-52.

Speroni S, De Colibus L, Mastrangelo E, Gould E, Coutard B, Forrester NL, Blanc S, Canard B, Mattevi A. Structure and biochemical analysis of Kokobera virus helicase. Proteins: Structure, Function, and Bioinformatics 2008, 70, 1120 – 1123.

 De Colibus L, Speroni S, Coutard B, Forrester NL, Gould E, Canard B, Mattevi A.Purification and crystallization of Kokobera virus helicase.Acta Cryst. Sect F Struct Biol Cryst Commun. 2007, 63, 193-195.


Leave a Reply